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KMID : 0377619760300030369
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Korean Jungang Medical Journal
1976 Volume.30 No. 3 p.369 ~ p.678
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Histopathological Observation on the Intestinal Metaplasia of the Gastric Mucosa in Carcinoma and Peptic Ulcer.of the Stomach
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Abstract
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An abnormal tissue element, intestinal epithelium, in the gastric mucosa is frequently observed in cases of gastric carcinomas and peptic ulcers in the stomach. This intestinal epithelium was considered as result of metaplastic change from gastric covering epithelium into intestinal type having goblet and Paneth cells in a few conditions such as carcinomas, inflammations or other chronic injuries. This study was to mestimate the frequency and degree of intestinal metaplasia in the mucosa of gastric carcinoma and peptic ulcer and what the further relation between carcinogenesis and intestinal metaplasia in the gastric mucosa.
The results observed are as follows￢;
1. The positive incidence was 95% of gastric carcinomas in total 100 cases of
patients, and 81.8% of peptic ulcers of the stomach in total 94 patients. The more.positive incidence, the more advanced ages was obvious in cases of peptic ulcers of the stomach.
2. In relationship between intensity of inflammatory reaction and intestinal metaplasia, there is no significant differences in them of both ,gastric carcinomas and peptic ulcers of the stomach.
3. Diffuse infiltrative type of gastric carcinomas is the most frequent type (62%) with incidence of intestinal metaplasia (3.6%), next, ulceroinfiltrative type (16%) with incidence of intestinal metaplasia (100%), next papillary type (15%), with incidence. (93.3%) and the least, early or superficial type (7%), with incidence (100%.).
4. The degree of mucin secretion in cancer cells is compared with, degree of intestinal metaplasia of the gastric mucosa. There is no significant differences in mucin secreting carcinomas and carcinomas. without mucinsecreting
activity.
5. The incidence of intestinal metaplasia of the gastric mucosa in higher, and possibly very close relationship with gastric carcinomas, bur there is no definite conclusion between carcinogenesis and intestinal metaplasia in the
gastric mucosa.
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KEYWORD
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